Co-Q10 Helps to Reduce Preeclampsia

Pre eclampsia, sometimes called toxemia, is a unique and often dangerous condition that only occurs during pregnancy. Most experts define PRE ECLAMPSIA as an elevation in blood pressure in a pregnant woman of 140/90, with protein in the urine, or swelling (edema) of the feet, hands, and face. The condition occurs more commonly during first pregnancies, with twins or triplets, in very young or older women, and when a woman has had pre eclampsia with previous pregnancies. In general, about 10-15% of women get this condition during their first pregnancy, while about 7% or women who have previously had children develop pre eclampsia with later pregnancies.

Findings of New Research on Co-Q10

A new study has found that CoQ10 can decrease the incidence of preeclampsia in pregnancy. This is great news for mother who have had preeclampsia in the past or who have a history of preeclampsia in their family. Below are some abstracts that talk about some of the many benefits of CoQ10. 

Abstract

OBJECTIVE: To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia. METHODS: Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat. RESULTS: Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96). CONCLUSION: Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.

Int J Gynaecol Obstet. 2009 Apr;105(1):43-5. Epub 2009 Jan 19.

Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.

Teran E, Hernandez I, Nieto B, Tavara R, Ocampo JE, Calle A.

Experimental Pharmacology and Cellular Metabolism Unit, Biomedical Center, Central University of Ecuador, Quito, Ecuador.

Abstract

The fundamental role of coenzyme Q(10) (CoQ(10)) in mitochondrial bioenergetics and its well-acknowledged antioxidant properties constitute the basis for its clinical applications, although some of its effects may be related to a gene induction mechanism. Cardiovascular disease is still the main field of study and the latest findings confirm a role of CoQ(10) in improving endothelial function. The possible relation between CoQ(10) deficiency and statin side effects is highly debated, particularly the key issue of whether CoQ(10) supplementation counteracts statin myalgias. Furthermore, in cardiac patients, plasma CoQ(10) was found to be an independent predictor of mortality. Studies on CoQ(10) and physical exercise have confirmed its effect in improving subjective fatigue sensation and physical performance and in opposing exercise-related damage. In the field of mitochondrial myopathies, primary CoQ(10) deficiencies have been identified, involving different genes of the CoQ(10) biosynthetic pathway; some of these conditions were found to be highly responsive to CoQ(10) administration. The initial observations of CoQ(10) effects in Parkinson’s and Huntington’s diseases have been extended to Friedreich’s ataxia, where CoQ(10) and other quinones have been tested. CoQ(10) is presently being used in a large phase III trial in Parkinson’s disease. CoQ(10) has been found to improve sperm count and motility on asthenozoospermia. Moreover, for the first time CoQ(10) was found to decrease the incidence of preeclampsia in pregnancy. The ability of CoQ(10) to mitigate headache symptoms in adults was also verified in pediatric and adolescent populations. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Nutrition. 2010 Mar;26(3):250-4. Epub 2009 Nov 22.

Clinical aspects of coenzyme Q10: an update.

Littarru GP, Tiano L.

Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy.

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